Patologia Generale (Farmacia)
AA 2015/2016
Scheda insegnamento
Mutuato da
Moduli
Obiettivi e risultati
Il corso intende fornire le conoscenze delle basi biologiche delle manifestazioni patologiche, individuando i principali fattori patogeni attivi sull’organismo umano e i meccanismi patogenetici responsabili delle alterazioni dell’omeostasi e dell’insorgenza delle malattie. In parallelo, si intende far acquisire allo studente elementi di terminologia medica e alcuni principi di fisiopatologia.
The student should comprehend major causes and pathogenic mechanisms leading to human disease and the fundamental defence biological mechanisms, with their alterations. Requisiti Nozioni di biologia generale, anatomia, chimica biologica, fisiologia. Essential requirements The student should know contents and relationships existing between basic disciplines (cell biology, human anatomy and physiology, biological chemistry).
Il candidato deve dimostrare di aver compreso e di saper esporre con esattezza di termini i meccanismi patogenetici e i principali argomenti di fisiopatologia.
The student should learn basic alterations of physiologic processes governing the function of tissues, organs and systems
Programma
INTRODUZIONE
{page:Section1;} -->
GENERAL PATHOLOGY: medical speciality concerned with the study of disease processes and how these provoke structural and functional changes in the body
PROGRAM
INTRODUCTION
Health and disease: concept of aetiology and pathogenesis
CELLULAR PATHOLOGY
Cell adaptation: hypertrophy, hyperplasia, atrophy, metaplasia, dysplasia
Mechanisms and patterns of cellular injury (necrosis and apoptosis)
Accumulations and pathological pigmentation
INFLAMMATION AND REPAIR
Acute inflammation: vascular phenomena, cellular recruitment and activation, cell adhesion molecules, mediators
Morphologic patterns of acute inflammation
Chronic inflammation: cellular involvement and mediators
Granulomatous inflammation: types of granuloma
Systemic effects of inflammation
Repair and wound healing: granulation tissue and scarring; primary and secondary intention
IMMUNOLOGY AND IMMUNOPATHOLOGY
The immune system: innate and adaptative response, lymphocytes, complement system, immunological memory
Pathogenesis of disorders of the immune system:
• hypersensitivity (type I: allergies and anaphylaxis; type II: antibody-mediated reactions, ADCC; type III: immune complex diseases; type IV: delayed type hypersensitivity)
• autoimmune disorders (immunological tolerance; classification)
• immune deficiency disorders (main primary and acquired immune deficiency)
ENVIRONMENTAL PATHOLOGY
Abiotic agents that influence human health: temperature, radiations, pressure, nutrition
GENETIC PATHOLOGY
Single gene disease: examples of autosomal dominant and recessive disorders, X-linked disorders
Disorders due to alterations in chromosome structure and numbers
Multifactorial disorders
ONCOLOGY
Cancer cell biology: clonal evolution and biological properties
Classification; stage and histological grading
Oncogenes and tumor suppressor genes
Carcinogenesis: chemical carcinogens and ionizing radiation; viral infection
Immune system dysfunction
Cachexia and metastasis
ALTERATIONS OF PHYSIOLOGIC PROCESSES
Fever
Gastrointestinal disease: gastritis, ulcer; enteritises (IBD)
Liver diseases: viral and toxic hepatitis; cirrhosis; hepatic insufficiency
Respiratory diseases: pulmonary infective diseases; obstructive and restrictive pulmonary disease; pulmonary hypertension; pulmonary insufficiency
Diabetes mellitus: pathophysiology, classification, acute and long-term complications
Kidney diseases: nephrotic and nephritic syndrome; glomerulonephritis; nephritic insufficiency
Blood disorders: anemias: pathopyhysiology, classification (haemolytic, from defect in erythroid precursors); hemorrhagic disorders
Circulatory disturbancies: atherosclerosis (atherogenesis and morphologic features with complications); thrombosis and its complications; hypo- and hypertension; shock; embolism, ischemia
Heart diseases: coronary heart disease; ischemic and hypertensive heart disease; heart failure
Testi consigliati
Robbins Cotran ‘LE BASI PATOLOGICHE DELLE MALATTIE’ ELSEVIER MASSON, Milano, VIII ed, 2010, I-II vol
Celotti ‘PATOLOGIA GENERALE E FISIOPATOLOGIA’ II ed, EdiSES, Napoli, 2013
Pontieri – Russo – Frati ‘PATOLOGIA GENERALE’, Piccin Nuova Libraria, Padova, IV ed, 2010 I-II vol
Pontieri 'PATOLOGIA GENERALE E FISIOPATOLOGIA GENERALE', Piccin Nuova Libraria, Padova, II ed, 2007
Nota
Il corso prevede lezioni frontali. Modalità d’esame: l’esame è svolto attraverso una prova scritta e un colloquio orale.
The course expects frontal lessons. The final exam will be based on a written and an oral test.
Insegnamenti che mutuano questo insegnamento
Orario lezioni
Appelli
Nessun appello.Avvisi
Nessun avviso recente.Materiale didattico
Storico
Altri link
Registrazione a questo insegnamento
Invia email